Recent events have not been kind to fans of global trade. Growing discontent with the status quo, particularly by major powers in the system like the United States, has led to a range of policy actions that would have been unthinkable just a decade ago. The disruptions caused by the Covid-19 pandemic further shattered consensus over what constitutes acceptable actions by governments. National security concerns are increasingly dominating economic decisions. In this rapidly evolving landscape, the global trade system is facing at least three major challenges. First, global leadership has been in short supply with significantly less enthusiasm for supporting past trade practices and solutions. Second, the proliferation of new trade arrangements comes with a growing risk of further trade splintering. Finally, if past practices are increasingly seen as inadequate, there is limited agreement on what sort of alternative arrangements might be better fit for purpose. Asia plays a pivotal role in designing outcomes for the future. This highly trade-dependent region has relied on the bedrock created by the World Trade Organization (WTO) to ensure trade lanes remain open and the use of broadly consistent rules to help govern trade. Connecting to others via trade does not solve all problems, but it remains a critical tool for driving growth and economic development. Now the WTO is stuck, with the consensus-based organization largely unable to move ahead on most of its agenda. Other than an agreement on trade facilitation, the WTO has not managed to get any new trade rules or market liberalization in place since 1995. Even the so-called “crown jewel” of the WTO, the dispute settlement system, has now been broken for several years. Restoring the multilateral system is an urgent priority, however, there is limited agreement on how to make it happen.